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pentobarbital will minimize the extent or effect of methadone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.pentobarbital will minimize the level or influence of tramadol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Lowered AUC of tramadol and also the Energetic metabolite (O-d